Hidekazu Tsukamoto Selected Research

Alcoholic Liver Diseases (Alcoholic Liver Disease)

4/2020	Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles.
1/2020	Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice.
1/2020	Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1β and IL-17 upregulation in alcoholic hepatitis mice.
1/2017	The let-7/Lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury.
1/2017	Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood.
3/2016	The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease.
1/2015	Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice.
9/2014	Alcohol, TLR4-TGF-β antagonism, and liver cancer.
7/2013	Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice.
9/2012	Epigenetic regulation of miR-34a expression in alcoholic liver injury.

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Hidekazu Tsukamoto Research Topics

Disease

19	Neoplasms (Cancer) 11/2020 - 02/2009
16	Alcoholic Liver Diseases (Alcoholic Liver Disease) 04/2020 - 02/2002
13	Liver Diseases (Liver Disease) 04/2020 - 02/2002
13	Liver Cirrhosis (Hepatic Cirrhosis) 01/2018 - 05/2004
12	Fibrosis (Cirrhosis) 04/2020 - 10/2005
8	Tics (Tic) 11/2020 - 07/2013
8	Inflammation (Inflammations) 01/2020 - 01/2004
8	Obesity 01/2016 - 10/2005
7	Hepatocellular Carcinoma (Hepatoma) 11/2020 - 08/2009
7	Carcinogenesis 11/2020 - 02/2009
7	Alcoholic Fatty Liver 01/2017 - 09/2008
6	Fatty Liver 01/2018 - 08/2011
5	Liver Neoplasms (Liver Cancer) 11/2018 - 08/2009
4	Alcoholic Hepatitis 11/2020 - 10/2016
3	Pancreatitis 01/2020 - 01/2008
3	Alcoholism (Alcohol Abuse) 01/2020 - 03/2012
3	Hypoxia (Hypoxemia) 01/2018 - 10/2009
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2017 - 01/2016
2	Non-alcoholic Fatty Liver Disease 01/2017 - 01/2016
2	Insulin Resistance 01/2016 - 10/2005
2	Endotoxemia 01/2016 - 02/2009
2	Hepatitis 01/2015 - 08/2007
2	Hyperhomocysteinemia 09/2011 - 07/2002
2	Melanoma (Melanoma, Malignant) 07/2011 - 10/2010
2	Hemochromatosis (Bronze Diabetes) 09/2008 - 02/2004
1	End Stage Liver Disease 01/2022
1	Cicatrix (Scar) 04/2020
1	Brain Injuries (Brain Injury) 01/2020
1	Genomic Instability 01/2017

Drug/Important Bio-Agent (IBA)

9	Ethanol (Ethyl Alcohol)IBA 01/2017 - 10/2009
7	Proteins (Proteins, Gene)FDA Link 01/2020 - 02/2009
6	NF-kappa B (NF-kB)IBA 01/2020 - 10/2002
5	CytokinesIBA 01/2022 - 01/2018
5	IronIBA 02/2015 - 06/2003
5	Messenger RNA (mRNA)IBA 02/2015 - 06/2003
4	MicroRNAs (MicroRNA)IBA 01/2020 - 09/2012
4	Interleukin-17 (Interleukin 17)IBA 01/2020 - 03/2016
4	Methionine (L-Methionine)FDA Link 06/2014 - 07/2002
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2005 - 02/2002
3	ChemokinesIBA 01/2022 - 01/2015
3	RNA (Ribonucleic Acid)IBA 11/2020 - 01/2020
3	Biomarkers (Surrogate Marker)IBA 01/2020 - 07/2014
3	CeruletideIBA 01/2020 - 01/2008
3	CholesterolIBA 01/2020 - 01/2018
3	Small Interfering RNA (siRNA)IBA 01/2018 - 02/2009
3	Diethylnitrosamine (N-Nitrosodiethylamine)IBA 03/2016 - 03/2012
3	necdinIBA 09/2015 - 10/2010
3	EndotoxinsIBA 04/2015 - 07/2013
2	NitrosaminesIBA 11/2020 - 01/2017
2	Stearoyl-CoA DesaturaseIBA 01/2020 - 01/2017
2	Epithelial Cell Adhesion MoleculeIBA 01/2020 - 01/2015
2	Liposomes (Liposome)IBA 01/2018 - 01/2017
2	AcetaldehydeIBA 01/2018 - 01/2017
2	Histones (Histone)IBA 01/2017 - 08/2015
2	3-deazaneplanocinIBA 01/2017 - 02/2010
2	Carbon Tetrachloride (Tetrachloromethane)IBA 06/2012 - 02/2010
2	LeptinIBA 01/2012 - 03/2010
2	Toll-Like Receptor 4IBA 08/2011 - 02/2009
2	AntigensIBA 07/2011 - 10/2010
2	S-Adenosylmethionine (Ademetionine)IBA 03/2010 - 08/2009
2	metal transporting protein 1 (ferroportin)IBA 11/2008 - 02/2004
2	Transferrin (beta 2 Transferrin)IBA 09/2008 - 02/2004
2	PPAR gammaIBA 12/2005 - 05/2004
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2022
1	AC133 AntigenIBA 11/2020
1	Collagen Type I (Type I Collagen)IBA 04/2020
1	Extracellular Matrix ProteinsIBA 04/2020
1	Interleukin-17 ReceptorsIBA 01/2020
1	IntegrinsIBA 01/2020
1	Biological ProductsIBA 01/2020
1	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA 01/2020
1	LipopolysaccharidesIBA 01/2020
1	nephronectinIBA 01/2020
1	fibroblast growth factor 21IBA 01/2020
1	Interleukin-6 (Interleukin 6)IBA 01/2020
1	S100 Calcium Binding Protein A6IBA 01/2020
1	Nicotine FDA Link 01/2020
1	GTP Phosphohydrolases (GTPases)IBA 11/2018
1	Mechanistic Target of Rapamycin Complex 1IBA 11/2018
1	baicaleinIBA 11/2018
1	TOR Serine-Threonine KinasesIBA 11/2018
1	Cardiolipins (Cardiolipin)IBA 01/2018
1	oxoglutarate translocatorIBA 01/2018
1	Dacarbazine (DIC)FDA LinkGeneric 01/2018
1	EstersIBA 01/2018
1	Cysteine (L-Cysteine)FDA Link 04/2017
1	Histone Deacetylases (Histone Deacetylase)IBA 04/2017
1	Matrix Metalloproteinases (MMPs)IBA 04/2017
1	CathepsinsIBA 04/2017
1	Cathepsin HIBA 04/2017
1	Histone MethyltransferasesIBA 01/2017
1	CateninsIBA 01/2017
1	LDL Receptors (LDL Receptor)IBA 01/2017
1	Epidermal Growth Factor (EGF)IBA 01/2017
1	Smad Proteins (Mothers Against Decapentaplegic Homolog)IBA 01/2017
1	Aldehyde DehydrogenaseIBA 01/2017
1	Sterol Regulatory Element Binding ProteinsIBA 01/2017

Therapy/Procedure

3	Therapeutics 01/2020 - 10/2016
3	Drug Therapy (Chemotherapy) 11/2018 - 03/2012
2	Liver Transplantation 01/2018 - 10/2006